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An analog of valeric acid; inhibits class I HDACs (IC50s = ~2 mM); decreases the number of axon branches in sensory neurons isolated from newborn rat dorsal root ganglia; inhibits amyloid-β deposition and neuritic plaque formation and decreases escape latency in the Morris water maze test in the APP23 transgenic mouse model of Alzheimer's disease; has anticonvulsant activity in the pentylenetetrazole seizure threshold test in mice (ED50 = 0.71 mmol/kg); induces neurotoxicity at ≥1.2 mmol/kg
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Glutamate-Ammonia Ligase Primary Antibody Unconjugated Public Immunogen Range 260-310/373 Host Species Rabbit Target Species Human Mouse Rat Clonality Monoclonal Applications WB FCM IC Concentration Lot dependent Size 50 ul Storage Buffer Supplied in PBS (pH 7 4) containing 50% glycerol and 0 02% sodium azide
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StatusFirst Mono Control Set - POS & NEG (2 x 0.5 ml) CLIA WAIVED for whole blood FDA cleared with no age restrictions Single reagent procedure provides results in 3-8 minutes Fingerstick whole blood convenience Superior 99.9% sensitivity for earlier IM detection, specificity of 98.8%New plastic sample transfer pipettes
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MW 282.81 g/mol, Purity >99%. Serotonin and norepinephrine reuptake inhibitor. IC₅₀ values are 100, 203 and >100000 nM for NA, 5-HT and DA, respectively. Centrally active following oral administration. Exhibits antidepressant and antifibromyalgia activity in vivo.
MW 960.8 Da, Purity >95%. Potent inhibitor of L-glutamate uptake via the membrane bound excitatory amino acid transporter (EAAT). Able to antagonize AMPA and kainate receptor mediated currents (IC₅₀ values are 220 and 150 nM, respectively). Binds with high affinity to serum albumin.